Laminar Flow Attenuates Macrophage Migration Inhibitory Factor Expression in Endothelial Cells

Macrophage Migration Inhibitory Factor

I-43: Expression Profile of Macrophage Migration Inhibitory Factor (MIF) Signaling Pathway as A Potentional Biomarker in Pathophysiology of Endometriosis

Background MIF via its receptor, CD74, initiates a signaling cascade that leads to proliferation and survival of cells. Also, MIF binding to CD74 activates p38 signaling pathways that lead to positive effect on the expression of COX-2. The aim of this study was to evaluate the gene expression profile of MIF, CD74 and COX-2 in normal, ectopic and eutopic endometrium during menstrual cycle. The e...

Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cells.

Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has been shown to play a role in wound-healing processes. In this study, we investigated whether protease-activated receptor (PAR)-1 and PAR-2 mediated MIF expression in human endothelial cells. Thrombin, factor Xa (FXa), and trypsin induced MIF expression in human dermal microvascular endothelial cells and human umbilica...

Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules.

Macrophage migration inhibitory factor (MIF) has been shown to promote leukocyte-endothelial cell interactions, although whether this occurs via an effect on endothelial cell function remains unclear. Therefore, the aims of this study were to examine the ability of MIF expressed by endothelial cells to promote leukocyte adhesion and to investigate the effect of exogenous MIF on leukocyte-endoth...

The expression of macrophage migration inhibitory factor in adenomyosis

The aim of the present study was to investigate whether the expression of macrophage migration inhibitory factor (MIF) is altered in eutopic endometrium and ectopic lesion of women with adenomyosis. MIF expression was assessed by immunohistochemistry, western blotting analysis. Elevated expression of MIF protein was seen in eutopic endometrium and ectopic lesion of women with adenomyosis (P<0.0...